Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance
Published in PLOS Computational Biology, 2021
Very high risk neuroblastoma is characterised by increased MAPK signalling. By generating quantitative perturbation data and mathematical modelling, we determined potential resistance mechanisms.
Recommended citation: Dorel M, Klinger B, Mari T, Toedling J, Blanc E, Messerschmidt C, et al. (2021) Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance. PLoS Comput Biol 17(11): e1009515. https://doi.org/10.1371/journal.pcbi.1009515 http://academicpages.github.io/files/paper1.pdf