CV

Work experience

• 2021 - today Bioinformatician in the group Gene Regulation and System Biology of Cancer, Max Plank Institute for Molecular Genetics, Berlin.
  • Design and analysis of a CROPseq dataset in paediatric cancer cell lines (B-ALL, ES, HB)
  • Design and analysis of a dropout screen with drug treatments in paediatric cancer cell lines
  • Maintenance and development of sequencing pipelines
• 2015 - 2021 PhD Reverse engineering signalling networks in neuroblastoma in the group of Computationnal Modelling in Medicine, Humboldt-Universität zu Berlin and Charité Universitätsmedizin, Berlin.
  • Development of the R/C++ package STASNet
  • Perturbation of a panel of neuroblastoma cell lines with targeted therapies
  • Modelling of cell line signalling

Education

• 2012 - 2015 M.S in Molecular and Cellular Biology with a specialisation in Bioinformatics, École Normale Supérieure and UPMC, Paris.
• 2010 - 2012 Classes préparatoires aux Grandes Ecoles BCPST , Hoches, Versailles.

Skills

• Tissue culture
• Sequencing on Illumina sequencers
• Single cell sequencing
  • 10X
  • Evercode
• Programming
  • R/tidyverse
  • python
  • C/C++

Publications

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance

Dorel M, Klinger B, Mari T, Toedling J, Blanc E, Messerschmidt C, et al. (2021) Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance. PLoS Comput Biol 17(11): e1009515. https://doi.org/10.1371/journal.pcbi.1009515